Canon is uncertain in this point. The only major being with massive implants and the force is Vader. The Emperor certainly thinks that Vader's connection to the force is deminished through his injuries. But the Jedi do not when he losses his arm on Geonosis. It also differs in HOW you think the force is expressed. A more mystical approch says no. There are sentiant force using Crystals that live in a droid body and use the force just fine. Someone's spritual connection can be nurtured and grown through ways like the Jedi use. Forcee ability is documented to grow through training and use. The other way is more scientific. The amount of midichlorians in a person determines force ability. But it is never clarified if it's per cell or the whole body or even if it's capible to change. Lucus seems to change his mind in that it starts out as more mystical in the original trilogy and more scientific in the prequels.
In total, it's how you personally view what the Force is and how it's expressed that will determine whether or not force ability can be deminished through loosing body parts. The Force is the perfect mind of matter situation. It is entirely possible that if you think it dimishes your ability, it will.