This is a spinoff question from Why aren't there any main Federation battleships in the Star Trek universe? The Defiant is presented as a Main Battleship but has also been described as 'just' a "Tough little ship" by Riker. Is there any other in-canon information regarding how well the Defiant has actually stood up against a Galaxy Class type starship in a knockdown drag-out fight or any direct references to firepower/durability simulations, scenarios, in universe comments, etc.?
Are there any ships of Galaxy (or comparable) Class that the Defiant has actually beaten in a fight?
EDIT: From what I've found, the Defiant could be comparable to a modern day U.S. Navy Destroyer. Just as the modern Destroyer, the Defiant is classified as an 'escort vessel'. The Defiant is obviously capable of delivering a decent amount of firepower from a small maneuverable platform as well as being able to take a bit of a pounding but can it really stand toe-to-toe with a Ship of The Line?


Homefront Part 2, the Defiant goes toe-to-toe with an Excelsior class cruiser fitted with upgraded weaponry. It held up just fine and could have easily destroyed the Excelsior class vessel if they really wanted to. The whole time, Worf was telling his crew to only disable them and not cause casualties if possible. – Derek Aug 30 '15 at 01:53