Esther is warned when she resists visiting Achashverosh that, if she demures, salvation would come from another source and וְאַ֥תְּ וּבֵית־אָבִ֖יךְ תֹּאבֵ֑דוּ "you and your father's house will perish."
But Esther's parents were dead and there is no mention of siblings (especially as her mother died in childbirth according to one version I heard).
Some meforshim tie this to the memory of Sha'ul; if his descendant (Esther) doesn't make up for his allowing Agag to live, she and her father's house will be lost through Sha'uls' sin -- from the Megillat Setarim via Sefaria:
והטעם היות כי המן נצמח ע"י חטא שאול באגג אשר הניחו חי ומזה יצא המן והוצרך שתהי' הצלה ע"י אסתר שהיא מזרע שאול ולזה אמר מרדכי שבאם ההצלה יעמוד ליהודים ממקום אחר ממילא היא ובית אבה יאבדו בחטא שאול שלא יתכפר לו (אלשיך):
but that still doesn't explain what her father's house IS and who it includes and how it would be lost. If the meaning is that SHE will die and thus not have children, would we associate her child with her father's house and not her husband's family's "house"?