Nagini is now said to be a Maledictus, not an Animagus.
J.K. Rowling specifically contradicts the idea that Fantastic Beasts: The Crimes of Grindelwald is suggesting that Nagini is meant to be an Animagus. Instead, she’s said to be a Maledictus, which JKR further states is very different from being an Animagus.

What some of these differences are already is made clear. From her further tweets on the subject of Maledictuses, and interviews released with new information on them, a good amount of the differences between them and Animagi can be deduced.
Animagi:
- Choose to become Animagi
- Have to go through the process of learning to become Animagi
- Can be either male or female
- Remain able to transform from animal to human, and don’t lose this ability with time
- Can’t inherit or pass down the ability - James Potter is an Animagus, his son Harry isn’t
- Are fully capable wizards who have wands and the ability to use magic
Maledictuses:
- Are cursed from birth
- Don’t ‘learn’ to transform as a skill
- Are only women
- Will eventually lose the ability to transform at will, and become a beast permanently
- Have a hereditary curse passed down from mother to daughter
- Don’t have wands and likely have different powers to wizards.
We know Maledictuses are only women who have a hereditary curse that’s passed through the female line because JKR says it in a tweet.

The actress playing Nagini in Fantastic Beasts: The Crimes of Grindelwald confirmed the transformation will eventually become permanent and she’ll remain a snake.
The actress reveals that when Crimes takes place in 1927, Nagini can transform from human to snake at will, yet due to her mysterious blood curse she knows that eventually, she’ll become a snake permanently. “She does feel sometimes it’s not controllable,” Kim says. “She is bound to [permanently] transform at some point to a beast so she feels this pressure that the clock is ticking.”
- Fantastic Beasts actress Claudia Kim breaks silence on playing Nagini (Entertainment Weekly)
She also says that her character doesn’t have a wand, and though she does have powers not explained yet, she mightn’t have the same powers as wizards.
“She has powers that are yet to be explored,” Kim says carefully. “I can’t confirm she has powers like wizards have. And she doesn’t have a wand.”
- Fantastic Beasts actress Claudia Kim breaks silence on playing Nagini (Entertainment Weekly)
Though both Animagi and Maledictuses can turn from human to animal, there are clear differences in both how they have this ability, and what having it means for them.
Logically, there’d be other Maledictuses - it’s a hereditary curse.
Though there’s only one Maledictus mentioned so far, it’s very likely there would be others. As it’s a hereditary curse passed from mother to daughter, it seems likely that Nagini’s mother would also have been a Maledictus, as well, and possibly some of her other female ancestors as well. It’s unclear as of yet where the Maledictus blood curse comes from, but she can’t be the only one in existence if it’s known to be a hereditary curse passed through the female line,
Maledictuses don’t always turn into snakes, however.
Though there are likely other Maledictuses, not all Maledictuses transform into snakes, they can be other creatures as well. J.K. Rowling said this in a tweet replying to a question.

So, how many Maledictuses will turn into snakes, rather than other creatures, still isn’t clear. It’s also not clear as of yet what specifically causes a Maledictus to transform into the creature it does.